General Information

ATG2A is a lipid transfer protein which helps in Isolation membrane (IM) expansion by tethering the edge of IM to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM (PMID:31271352, PMID:30952800). ATG2 family exhibits a rod-like structure, approximately 20 nm in length (PMID: 30911189). They interact with the endoplasmic reticulum exit site (ERES) using one end and simultaneously bind to the isolation membrane (IM) using the opposite end, extract phospholipids from this membrane source and transfer them to ATG9 (ATG9A or ATG9B) for membrane expansion (PMID:31271352, PMID:30952800). The lipid transfer activity of ATG2A is augmented by WIPI1 and WIPI4, which enhances ATG2A's association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PMID:31271352).

Sequence 3D-Structure Experimental Structures

Peptide Bound

AlphaFold Structures