General Information

ATG9B functions as a phospholipid scramblase protein, facilitating the expansion of autophagosomal membranes by distributing phospholipids from the endoplasmic reticulum (ER) to the Isolation membrane (IM) through the involvement of ATG2A/ATG2B. While ATG9A is predominantly found in the placenta and pituitary gland, suggesting a specialized role (PMID: 32139519), ATG9B has been implicated in tumorigenesis, particularly in hepatocellular carcinoma (PMID: 28740555). It has been proposed as a potential target for autophagy inhibition in gliomas (PMID: 35882624). Cryo-electron microscopy (cryoEM) maps of ATG9B have unveiled a comparable topology to ATG9A, indicating that ATG9B also forms a homotrimeric structure (PMID: 37938170).

Sequence 3D-Structure Experimental Structures

Homo-Oligomer

AlphaFold Structures