WIPI1 is a crucial protein involved in autophagy initiation. During starvation, it functions upstream of both ATG7 and ATG5, and stimulates an increase of LC3-II. It becomes an autophagosomal membrane protein through binding to PtdIns(3)P and then accumulating at phagophore (PMID: 22082875). It has been reported that WIPI1 interacts with both WIPI2 and ATG16L1. However, the interaction strength with ATG16L1 is found to be less compared to WIPI2 (PMID: 24954904, 28561066). Experiments suggest that the loss of WIPI1 impacts autophagy induction in response to the viral infection (PMID: 23051912).
Experimental structure not availabe
Representations
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