RB1CC1 (Uniprot: Q8TDY2)


Structure      Interactors       Orthologs
General Information

RB1CC1 (otherwise known as FIP200) is an integral component of the ULK complex and is recruited in the initial stages of autophagy. ULK complex gets activated due to the interaction of ATG11 with RB1CC1 and this interaction is considered to be essential for the induction of autophagy (PMID: 31238043). Apart from its active role in the ULK complex, its interaction with ATG16L1 is also reported to be critical for autophagosomal growth by targeting ATG16L1 towards the phagophore (PMID: 23392225, 23262492).


Available Structures


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RB1CC1 Orthologs
ORTHODB_ID UNIPROT_ID UNIPROT Entry Name Reviewed Protein name (as given in UNIPROT) Gene Name (as given in UNIPROT) Protein name (as given in ORTHODB) Organism Length AF Structure Availability AFDB_ID pLDDT
0 6210_0:00182f W6UGB3 W6UGB3_ECHGR unreviewed Autophagy-related protein 11 C-terminal domain-containing protein EGR_05172 ATG11 domain-containing protein Echinococcus granulosus (Hydatid tapeworm) 261 Available AF-W6UGB3-F1.pdb 54.3882
1 407821_0:000b25 A0A087T2I0 A0A087T2I0_STEMI unreviewed RB1-inducible coiled-coil protein 1 X975_11371 A0A087T2I0_STEMI Stegodyphus mimosarum (African social velvet spider) 639 Available AF-A0A087T2I0-F1.pdb 71.36286
2 121845_0:001275 A0A1S3CX68 A0A1S3CX68_DIACI unreviewed Uncharacterized protein LOC103507005 LOC103507005 LOC103507005 Diaphorina citri (Asian citrus psyllid) 205 Available AF-A0A1S3CX68-F1.pdb 75.28415
3 7955_0:005f86 E7FFM2 E7FFM2_DANRE unreviewed RB1-inducible coiled-coil 1 (RB1-inducible coiled-coil protein 1) rb1cc1 rb1cc1 Danio rerio (Zebrafish) (Brachydanio rerio) 1622 Available AF-E7FFM2-F1.pdb 71.61288
4 37040_0:001b67 A0A093F654 A0A093F654_GAVST unreviewed RB1-inducible coiled-coil protein 1 N328_06868 A0A093F654_GAVST Gavia stellata (Red-throated diver) (Colymbus stellatus) 1157 Available AF-A0A093F654-F1.pdb 71.49813
5 9606_0:00214a Q8TDY2 RBCC1_HUMAN reviewed RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) RB1CC1 KIAA0203 RBICC RB1-inducible coiled-coil protein 1 Homo sapiens (Human) 1594 Available AF-Q8TDY2-F1.pdb 72.24368
6 7244_0:0003f4 A0A0Q9WFT5 A0A0Q9WFT5_DROVI unreviewed Uncharacterized protein, isoform H Dvir\GJ23957 Dvir_GJ23957 Dvir\\GJ23957 Drosophila virilis (Fruit fly) 1107 Available AF-A0A0Q9WFT5-F1.pdb 71.64647
7 121845_0:003fe5 A0A1S3DL11 A0A1S3DL11_DIACI unreviewed RB1-inducible coiled-coil protein 1-like LOC103520418 LOC103520418 Diaphorina citri (Asian citrus psyllid) 462 Available AF-A0A1S3DL11-F1.pdb 71.33913
8 7029_0:00010b J9LC75 J9LC75_ACYPI deleted Ubiquitin-like domain-containing protein Available AF-J9LC75-F1.pdb 71.78996
9 50390_0:003a10 A0A6P7GQ00 A0A6P7GQ00_DIAVI unreviewed RB1-inducible coiled-coil protein 1-like LOC114341526 LOC114341526 Diabrotica virgifera virgifera (western corn rootworm) 1177 Available AF-A0A6P7GQ00-F1.pdb 64.81282
10 1049336_0:003881 A0A6L5CW61 A0A6L5CW61_9INSE unreviewed Autophagy protein ATG17-like domain-containing protein B566_EDAN014466 A0A6L5CW61_9INSE Ephemera danica 926 Available AF-A0A6L5CW61-F1.pdb 73.99888
11 407821_0:000b2b A0A087T2H8 A0A087T2H8_STEMI unreviewed RB1-inducible coiled-coil protein 1 X975_11369 A0A087T2H8_STEMI Stegodyphus mimosarum (African social velvet spider) 231 Available AF-A0A087T2H8-F1.pdb 85.83675
12 50390_0:00413f A0A6P7GX36 A0A6P7GX36_DIAVI unreviewed RB1-inducible coiled-coil protein 1-like LOC114343982 LOC114343982 Diabrotica virgifera virgifera (western corn rootworm) 215 Available AF-A0A6P7GX36-F1.pdb 85.05986
13 104452_0:001296 A0A0L7LH57 A0A0L7LH57_OPEBR unreviewed Putative rb1-inducible coiled-coil 1 OBRU01_08592 A0A0L7LH57_9NEOP Operophtera brumata (Winter moth) (Phalaena brumata) 382 Available AF-A0A0L7LH57-F1.pdb 48.55832
14 7227_0:002878 Q7KTS2 Q7KTS2_DROME unreviewed Autophagy-related 17, isoform B (Autophagy-related 17, isoform C) (FI18010p1) Atg17 atg17 CG1347-RB dAtg17 Dmel\CG1347 FIP200 Fip200 fip200 RB1CC1 CG1347 Dmel_CG1347 Atg17 Drosophila melanogaster (Fruit fly) 1357 Available AF-Q7KTS2-F1.pdb 65.89195
15 1629725_0:0007ef A0A0T6BC51 A0A0T6BC51_9SCAR unreviewed Ubiquitin AMK59_932 A0A0T6BC51_9SCAR Oryctes borbonicus 100 Available AF-A0A0T6BC51-F1.pdb 87.5432
16 10228_0:001815 B3RY68 B3RY68_TRIAD unreviewed Uncharacterized protein TRIADDRAFT_56455 ATG11 domain-containing protein Trichoplax adhaerens (Trichoplax reptans) 1041 Available AF-B3RY68-F1.pdb 66.47413
17 1629725_0:00035f A0A0T6BFG8 A0A0T6BFG8_9SCAR unreviewed Uncharacterized protein AMK59_2 ATG11 domain-containing protein Oryctes borbonicus 995 Available AF-A0A0T6BFG8-F1.pdb 72.73197
18 6412_0:000ec4 T1FS14 T1FS14_HELRO unreviewed Ubiquitin-like domain-containing protein 20211611 HELRODRAFT_190489 20211611 Helobdella robusta (Californian leech) 386 Available AF-T1FS14-F1.pdb 85.01409
19 74869_0:003876 A0A182S9F3 A0A182S9F3_9DIPT unreviewed Autophagy protein ATG17-like domain-containing protein A0A182S9F3_9DIPT Anopheles maculatus 547 Available AF-A0A182S9F3-F1.pdb 72.15872
20 6958_0:00296f A0A1Y3B0N6 A0A1Y3B0N6_EURMA unreviewed Synaptonemal complex protein 1-like protein BLA29_005950 A0A1Y3B0N6_EURMA Euroglyphus maynei (Mayne's house dust mite) 384 Available AF-A0A1Y3B0N6-F1.pdb 89.15406
21 400682_0:0009ad A0A1X7VKT6 A0A1X7VKT6_AMPQE unreviewed Autophagy-related protein 11 C-terminal domain-containing protein 100637661 ATG11 domain-containing protein Amphimedon queenslandica (Sponge) 895 Available AF-A0A1X7VKT6-F1.pdb 66.06815
22 418985_0:0015f6 A0A1V9XML0 A0A1V9XML0_9ACAR unreviewed RB1-inducible coiled-coil protein 1-like BIW11_03371 A0A1V9XML0_9ACAR Tropilaelaps mercedesae 1191 Available AF-A0A1V9XML0-F1.pdb 71.14887
23 6958_0:00280a A0A1Y3AZN0 A0A1Y3AZN0_EURMA unreviewed Uncharacterized protein BLA29_007950 A0A1Y3AZN0_EURMA Euroglyphus maynei (Mayne's house dust mite) 266 Available AF-A0A1Y3AZN0-F1.pdb 79.77541
24 7054_0:003160 A0A1Y1NID2 A0A1Y1NID2_PHOPY unreviewed Uncharacterized protein PPYR_08105 ATG11 domain-containing protein Photinus pyralis (Common eastern firefly) (Lampyris pyralis) 1175 Available AF-A0A1Y1NID2-F1.pdb 73.65493
25 6239_0:004c42 Q22342 Q22342_CAEEL unreviewed Autophagy-related protein 11 C-terminal domain-containing protein epg-7 atg-11 CELE_T08A9.1 T08A9.1 epg-7 Caenorhabditis elegans 1338 Available AF-Q22342-F1.pdb 68.29377
26 121224_0:000ee1 E0VTR8 E0VTR8_PEDHC unreviewed Protein NUF1, putative 8230582 Phum_PHUM436830 8230582 Pediculus humanus subsp. corporis (Body louse) 1257 Available AF-E0VTR8-F1.pdb 68.55846
27 7200_0:000301 A0A1B0C9Y8 A0A1B0C9Y8_LUTLO unreviewed Putative dna-binding transcription factor interacts with stathmin A0A1B0C9Y8_LUTLO Lutzomyia longipalpis (Sand fly) 1261 Available AF-A0A1B0C9Y8-F1.pdb 65.90554
28 13249_0:002630 T1HXJ7 T1HXJ7_RHOPR unreviewed Uncharacterized protein ATG11 domain-containing protein Rhodnius prolixus (Triatomid bug) 1059 Available AF-T1HXJ7-F1.pdb 72.58462
29 104452_0:001e47 A0A0L7L8T1 A0A0L7L8T1_OPEBR unreviewed Putative rb1-inducible coiled-coil 1 OBRU01_13203 A0A0L7L8T1_9NEOP Operophtera brumata (Winter moth) (Phalaena brumata) 913 Available AF-A0A0L7L8T1-F1.pdb 63.30702
30 121845_0:001270 A0A3Q0IT10 A0A3Q0IT10_DIACI unreviewed RB1-inducible coiled-coil protein 1-like LOC103507010 LOC103507010 Diaphorina citri (Asian citrus psyllid) 441 Available AF-A0A3Q0IT10-F1.pdb 76.99029
31 225164_0:00138f V4B2N2 V4B2N2_LOTGI unreviewed Ubiquitin-like domain-containing protein LOTGIDRAFT_112121 V4B2N2_LOTGI Lottia gigantea (Giant owl limpet) 100 Available AF-V4B2N2-F1.pdb 87.5963
32 51031_0:0042ea W2SKW0 W2SKW0_NECAM unreviewed RB1-inducible coiled-coil protein 1 NECAME_05014 W2SKW0_NECAM Necator americanus (Human hookworm) 930 Available AF-W2SKW0-F1.pdb 75.05433
33 74869_0:002b6b A0A182SVD8 A0A182SVD8_9DIPT unreviewed Autophagy-related protein 11 C-terminal domain-containing protein ATG11 domain-containing protein Anopheles maculatus 376 Available AF-A0A182SVD8-F1.pdb 83.0571
34 34506_0:00249d A0A090N0U1 A0A090N0U1_STRRB unreviewed RB1-inducible coiled-coil protein 1 SRAE_X000060500 A0A090N0U1_STRRB Strongyloides ratti (Parasitic roundworm) 995 Available AF-A0A090N0U1-F1.pdb 68.36144
35 43041_0:000749 A0A182K0Y7 A0A182K0Y7_9DIPT unreviewed Autophagy-related protein 11 C-terminal domain-containing protein ATG11 domain-containing protein Anopheles christyi 905 Available AF-A0A182K0Y7-F1.pdb 60.53975
36 29031_0:001e74 A0A1B0DHX6 A0A1B0DHX6_PHLPP unreviewed Uncharacterized protein A0A1B0DHX6_PHLPP Phlebotomus papatasi (Sandfly) 148 Available AF-A0A1B0DHX6-F1.pdb 83.34459
37 407821_0:000b21 A0A087T2H9 A0A087T2H9_STEMI unreviewed RB1-inducible coiled-coil protein 1 X975_11370 A0A087T2H9_STEMI Stegodyphus mimosarum (African social velvet spider) 53 Available AF-A0A087T2H9-F1.pdb 88.08585
38 1049336_0:001758 A0A6L5CC70 A0A6L5CC70_9INSE unreviewed Uncharacterized protein B566_EDAN005977 ATG11 domain-containing protein Ephemera danica 1088 Available AF-A0A6L5CC70-F1.pdb 67.14851
39 10116_0:001e41 D3ZHK4 D3ZHK4_RAT unreviewed RB1-inducible coiled-coil 1 Rb1cc1 Rb1cc1 Rattus norvegicus (Rat) 1588 Available AF-D3ZHK4-F1.pdb 71.67853
40 10090_0:000126 Q9ESK9 RBCC1_MOUSE reviewed RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (FAK family kinase-interacting protein of 200 kDa) (FIP200) (LaXp180) Rb1cc1 Cc1 Kiaa0203 RB1-inducible coiled-coil protein 1 Mus musculus (Mouse) 1588 Available AF-Q9ESK9-F1.pdb 72.21115
41 52283_0:001191 A0A132A5C2 A0A132A5C2_SARSC unreviewed Synaptonemal complex protein 1-like protein QR98_0046070 A0A132A5C2_SARSC Sarcoptes scabiei (Itch mite) (Acarus scabiei) 949 Available AF-A0A132A5C2-F1.pdb 72.19848
42 6412_0:000eda T1F0K1 T1F0K1_HELRO unreviewed Autophagy-related protein 11 C-terminal domain-containing protein 20202351 HELRODRAFT_168407 ATG11 domain-containing protein Helobdella robusta (Californian leech) 173 Available AF-T1F0K1-F1.pdb 60.45081
43 43041_0:0021c6 A0A182KD57 A0A182KD57_9DIPT unreviewed Autophagy protein ATG17-like domain-containing protein A0A182KD57_9DIPT Anopheles christyi 720 Available AF-A0A182KD57-F1.pdb 73.948
44 224129_0:001e02 A0A1W4XKW6 A0A1W4XKW6_AGRPL unreviewed RB1-inducible coiled-coil protein 1 isoform X1 LOC108745072 LOC108745072 Agrilus planipennis (Emerald ash borer) (Agrilus marcopoli) 1255 Available AF-A0A1W4XKW6-F1.pdb 70.56203
45 568069_0:00106b A0A1J1HVC7 A0A1J1HVC7_9DIPT unreviewed Alkaline phosphatase (EC 3.1.3.1) CLUMA_CG004981 Alkaline phosphatase Clunio marinus 530 Available AF-A0A1J1HVC7-F1.pdb 91.07219
46 6956_0:0018a9 A0A6P6XY51 A0A6P6XY51_DERPT unreviewed RB1-inducible coiled-coil protein 1-like LOC113792273 LOC113792273 Dermatophagoides pteronyssinus (European house dust mite) 1190 Available AF-A0A6P6XY51-F1.pdb 68.45747
47 407821_0:000b2e A0A087T2I1 A0A087T2I1_STEMI unreviewed RB1-inducible coiled-coil protein 1 X975_11372 A0A087T2I1_STEMI Stegodyphus mimosarum (African social velvet spider) 397 Available AF-A0A087T2I1-F1.pdb 73.52559
48 67767_0:00253a A0A0J7KHN3 A0A0J7KHN3_LASNI unreviewed Rb1-inducible coiled-coil protein 1 RF55_10341 A0A0J7KHN3_LASNI Lasius niger (Black garden ant) 92 Available AF-A0A0J7KHN3-F1.pdb 89.5987
49 51031_0:0042f5 W2SKJ4 W2SKJ4_NECAM unreviewed Autophagy-related protein 11 C-terminal domain-containing protein NECAME_05015 ATG11 domain-containing protein Necator americanus (Human hookworm) 109 Available AF-W2SKJ4-F1.pdb 85.62037
50 126957_0:00122d T1IRC5 T1IRC5_STRMM unreviewed Autophagy protein ATG17-like domain-containing protein T1IRC5_STRMM Strigamia maritima (European centipede) (Geophilus maritimus) 528 Available AF-T1IRC5-F1.pdb 83.16816
51 7957_0:00cb46 A0A6P6PGF2 A0A6P6PGF2_CARAU unreviewed RB1-inducible coiled-coil protein 1-like LOC113099021 LOC113099021 Carassius auratus (Goldfish) 337 Available AF-A0A6P6PGF2-F1.pdb 75.71226
52 6279_0:0025d3 A0A4E9EUF5 A0A4E9EUF5_BRUMA unreviewed Uncharacterized protein Bma-epg-7 BM_BM5668 ATG11 domain-containing protein Brugia malayi (Filarial nematode worm) 1133 Available AF-A0A4E9EUF5-F1.pdb 65.85036
53 225164_0:00147b V4AZX1 V4AZX1_LOTGI unreviewed Autophagy-related protein 11 C-terminal domain-containing protein LOTGIDRAFT_78353 ATG11 domain-containing protein Lottia gigantea (Giant owl limpet) 89 Available AF-V4AZX1-F1.pdb 95.35573
54 32264_0:001611 T1KEB9 T1KEB9_TETUR unreviewed Ubiquitin-like domain-containing protein 107363075 Ubiquitin-like domain-containing protein Tetranychus urticae (Two-spotted spider mite) 777 Available AF-T1KEB9-F1.pdb 75.88378
55 7220_0:0002de B3P2I4 B3P2I4_DROER unreviewed GG12986 Dere\GG12986 Dere_GG12986 Dere\\GG12986 Drosophila erecta (Fruit fly) 1261 Available AF-B3P2I4-F1.pdb 66.6193
56 7230_0:000e12 A0A0Q9WXF7 A0A0Q9WXF7_DROMO unreviewed Uncharacterized protein, isoform C Dmoj\GI23775 Dmoj_GI23775 Dmoj\\GI23775 Drosophila mojavensis (Fruit fly) 1102 Available AF-A0A0Q9WXF7-F1.pdb 71.84694
57 7209_0:001187 A0A1S0TVM9 A0A1S0TVM9_LOALO unreviewed Uncharacterized protein LOAG_07497 ATG11 domain-containing protein Loa loa (Eye worm) (Filaria loa) 1168 Available AF-A0A1S0TVM9-F1.pdb 64.24611
58 742174_0:001a95 A0A2H8TQN8 A0A2H8TQN8_9HEMI unreviewed RB1-inducible coiled-coil protein 1 RB1CC1_3 RB1CC1_3 Melanaphis sacchari 1039 Available AF-A0A2H8TQN8-F1.pdb 72.2019